Head- and neck cancer The cancers in head- and neck region have been promising targets for gene therapy. At the moment the most common method for clinical gene therapy in head- and neck cancers has been the use of conditionally replicating adenoviruses for the cancer treatment.  |  | The viruses penetrate to the cancer cells, which contain a mutation in their p53 tumor suppressor gene. The conditionally replicating adenovirus contains a mutation in the viral genome, allowing the replication only in those cells which contain the non-functional form of the p53. While copying itself, the virus destroys the host cells and new viruses can spread the infection to other cancer cells. |
More information can be found from www.docrates.fi and http://www.sunwaybio.com.cn/e041oat.htm
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